RNA Synthesis and Modification IVT Product Portfolio

RNase Inhibitors

There are many applications in which it is important to maintain the integrity of RNA. NEB offers three separate ribonuclease inhibitors (RNase inhibitors); Ribonucleoside Vanadyl Complex (NEB #S1402) can be used in cell fractionation methods, as well as in sucrose-gradient centrifugation to inhibit various ribonucleases; while RNase Inhibitor, Human Placenta (NEB #M0307) or RNase Inhibitor, Murine (NEB #M0314) can be used for inhibition of RNases A, B and C. The advantage of RNase Inhibitor, Murine, is that it lacks a pair of easily-oxidized cysteines that are present in the human form, thereby making it more stable.

For applications requiring larger scales, such nucleic acid therapeutic manufacturing workflow, NEB can supply these products in bulk and GMP-grade* formats (Murine RNase Inhibitor only).

 

* "GMP-grade" is a branding term NEB uses to describe products manufactured or finished at NEB’s Rowley facility. The Rowley facility was designed to manufacture products under more rigorous infrastructure and process controls to achieve more stringent product specifications and customer requirements. Products manufactured at NEB’s Rowley facility are manufactured in compliance with ISO 9001 and ISO 13485 quality management system standards. However, at this time, NEB does not manufacture or sell products known as Active Pharmaceutical Ingredients (APIs), nor does NEB manufacture its products in compliance with all of the Current Good Manufacturing Practice regulations.


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Protocols for RNase Inhibitors
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This product is intended for research purposes only. This product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.