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Epigenetics

Epigenetics

Epigenetics is the study of heritable changes in gene expression that are not encoded in the DNA of the genome. Encouraging evidence has linked epigenetic effects to oncogenesis, progression and treatment of cancer (1), the regulation of development and function of the nervous system (2), gene regulation (3), cellular stress events (3), nutrigenomics (4), aging and DNA repair (5). Considerable ongoing efforts are directed towards identifying the dynamic functions of various modifications to DNA and its associated proteins and elucidating their mechanisms.

References

  1. Baylin, S. and Jones, P. (2011) Nature Rev Cancer (10), 726-734. PMID: 21941284 
  2. Riccio, A., (2010) Nature Neuroscience, 13, 1330-1337. PMID: 20975757 
  3. Huang, J. et al. (2006) Nature, 444, 629-632. PMID: 17108971 
  4. Park, L.K., Friso, S. and Choi, S.W. (2011) Proc. Nutr. Soc. Nov 4, 1-9. 
  5. Pahlich, S., Zakaryan, R.P. and Gehring., H. (2006) Biochim, Biophys. Acta. 1764, 1890-1903. PMID: 17010682

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Epigenetics includes these areas of focus:
Antibodies
ChIP
Control DNA for Epigenetics
DNA Enrichment
DNA Methylation Analysis
5-hmC Detection & Analysis
Bisulfite Conversion
Methylated DNA Analysis
Histones & Nucleosome Assembly
Restriction Enzymes for Epigenetics
FAQs for Epigenetics
Application Notes for Epigenetics
    Publications related to Epigenetics
  1. Woodcock, C.B.l, Yu, D., Hajian, T., Li, J., Huang, Y., Dai, N., Corrêa, I.R., Jr., Wu, T., Vedadi, M., Zhang, X., Cheng, X 2019. Human MettL3 MettL14 complex is a sequence specific DNA adenine methyltransferase active on single strand and unpaired DNA in vitro Cell Discov. 5:63, PubMedID: 31885874, DOI: 10.1038/s41421-019-0136-4
  2. Murray, Iain; Morgan, Rick; Luyten, Yvette; Fomenkov, Alexey; Correa, Ivan; Dai, Nan; Roberts, Rich; 2018. The non-specific adenine DNA methyltransferase M.EcoGII. Nucleic Acids Research. (2), PubMedID: 29228259, DOI: 10.1093/nar/gkx1191
  3. Marx V. 2016. Genetics: profiling DNA methylation and beyond Nature Methods. 13, PubMedID: , DOI: 10.1038/nmeth.3736
  4. Mooijman D, Dey S S, Boisset JC, Crosetto N, van Oudenaarden A 2016. Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction Nature Biotechnology. 34, PubMedID: 27347753, DOI: 10.1038/nbt.3598
  5. Chernov AV., Reyes L., Peterson S., Strongin AY. 2015. Depletion of CG-Specific Methylation in Mycoplasma hyorhinis Genomic DNA after Host Cell Invasion PLoS One. 10, PubMedID: 26544880, DOI: 10.1371/journal.pone.0142529
  6. Kienhöfer S., Musheev M., Stapf U., Helm M., Schomacher L., Niehrs C., Schäfer A. 2015. GADD45a physically and functionally interacts with TET1Publication Differentiation. , PubMedID: 26546041, DOI: 10.1016/j.diff.2015.10.003
  7. Pirone-Davies, C., Hoffmann, M., Roberts, R.J., Muruvanda, T., Timme, R.E., Strain, E., Luo, Y., Payne, J., Luong, K., Song, Y., Tsai, Y.C., Boitano, M., Clark, T.A., Korlach, J., Evans, P.S., Allard, M.W. 2015. Genome-Wide Methylation Patterns in Salmonella enterica Subsp. enterica Serovars PLoS One. 10(4), PubMedID: 25860355, DOI:
  8. Page A., Paoli P., Salvador E., White S., French J., Mann J. 2015. Hepatic Stellate Cell Transdifferentiation Involves Genome-Wide Remodeling of the DNA Methylation Landscape J Hepatol. , PubMedID: 26632634, DOI: 10.1016/j.jhep.2015.11.024
  9. Wee E., Ngo T., Trau M. 2015. A simple bridging flocculation assay for rapid, sensitive and stringent detection of gene specific DNA methylation Sci Rep. 5, PubMedID: 26458746, DOI: 10.1038/srep15028
  10. Estève P., Zhang G., Ponnaluri V., Kanneganti 2015. Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates Nucleic Acids Res. , PubMedID: 26553800, DOI: 10.1093/nar/gkv1162
  11. Pais, J.E., Dai, N., Tamanaha, E., Vaisvila, R., Fomenkov, A.I., Bitinaite, J., Sun, Z., Guan, S., Correa, I.R. Jr., Noren, C.J., Cheng, X., Roberts, R.J., Zheng, Y. and Saleh, L. 2015. Biochemical characterization of a Naegleria TET-like oxygenase and its application in single molecule sequencing of 5-methylcytosine Proc Natl Acad Sci USA. 112(14), PubMedID: 25831492, DOI:
  12. Chandra S, Baribault C, Lacey M, Ehrlich M 2014. Myogenic differential methylation: diverse associations with chromatin structure Biology (Basel). 3(2), PubMedID: 24949935, DOI: 10.3390/biology3020426
  13. Hughes J.R., Roberts N., McGowan S., Hay D., Giannoulatou E., Lynch M., De Gobbi M., Taylor S., Gibbons R., Higgs D.R. 2014. Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment Nat Genet. 46 (2), PubMedID: 24413732, DOI: doi:10.1038/ng.2871
  14. Sexton T, Kurukuti S, Mitchell JA, Umlauf D, Nagano T, Fraser P 2012. Sensitive detection of chromatin coassociations using enhanced chromosome conformation capture on chip Nat Protoc. 7(7), PubMedID: 22722369, DOI: 10.1038/nprot.2012.071
  15. Wolff, E.M. et al. 2011. Hypomethylation of a LINE-1 Promoter Activates an Alternate Transcript of the MET Oncogene in Bladders with Cancer PLoS Genet. . 6, PubMedID: 20421991, DOI:
  16. Lieberman-Aiden E., van Berkum N., Williams L., Imakaev M., Ragoczy T., Telling A., Amit I., Lajoie B., Sabo P., Dorschner M., Sandstrom R., Bernstein B., BenderM. A., Groudine M., Gnirke A., Stamatoyannopoulos J., Mirny L., Lander E., Dekker J. 2009. Comprehensive mapping of long range interactions reveals folding principles of the human genome Science. Oct 9; 326(5950) , PubMedID: , DOI:
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Videos

  1. What is Epigenetics?

    What Is Epigenetics?

    If all cells are created from the same genetic material, why are there so many different cell types? Listen to Sriharsa Pradhan, Senior Scientist, RNA Biology at NEB, as he describes how DNA is methylated and how this affects the path of reading the DNA code the same way an obstruction would derail a train off its tracks.

  2. Epigenetics_Tutorial_TN

    Interactive Tutorial Explaining the Phenomenon of Epigenetics at a Molecular Level

    Watch an interactive tutorial explaining the different molecular mechanisms by which epigenetic change influences gene expression. Learn about how NEB’s reagents are targeted to the various enzymes and DNA elements that are altered by epigenetic change.

  3. PradhanSriharsa

    Restriction Enzymes in Chromatin Conformation Capture

    Chromatin conformation capture (3C) techniques allow study of the spatial organization of eukaryotic chromosomes in a 3D context.

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